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KMID : 0380019950100040358
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Korean Journal of Biotechnology and Bioengineering
1995 Volume.10 No. 4 p.358 ~ p.369
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Mathematical Model for Adsorption of Berberine on Encapsulated Adsorbent
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Choi, Jeng Woo/최정우
Cho, Sang Won/Lee, Won Hong/조상원/이원홍
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Abstract
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A mathematical model using local thermodynamic equilibrium isotherms for adsorption in encapsulated adsorbent is proposed in order to optimize the design parameters in in situ bioproduct separation process. The model accurately follows the experimental data on the adsorption of berberine, secondary metabolite produced in Thaictrum rugosum plant cell culture. The adsorption rate on encapsulated adsorbent is compared with that on alginate-entrapped adsorbent. The result shows that the higher loading capacity in encapsulated adsorbent is mainly due to the increase in the maximum solid phase concentration. Based on the adsorption rate and loading capacity, the encapsulated adsorbent would be more useful than the entrapped adsorbent when used in in situ bioproduct separation process. Design parameters in in situ bioproduct separation process, such as the size of the capsule, membrane thickness, the ratio of capsule volume to bulk volume, the ratio of single capsule volume to total capsule volume and the adsorbent content in the capsule, are evaluated by using the model. The ratio of single capsule volume to total capsule volume is the most effective parameter for adsorption of berberine or encapsulated adsorbent.
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